Metrolab Blog

THERMO Scientific Vanquish Method Development HPLC and UHPLC Systems

Automated and accelerated method development
Accelerate and automate your method development using Thermo Scientific Vanquish Method Development HPLC and UHPLC systems. These systems can optimize separation conditions by testing different combinations of buffers on up to six HPLC columns. Vanquish Method Development HPLC and UHPLC systems use Thermo Scientific Chromeleon Chromatography Data System (CDS), which features downloadable eWorkflows to simplify automated column and buffer scouting while enabling secure and central data storage. Achieve fully automated method development with ChromSwordAuto Chromeleon Connect and ChromSword AutoRobust Chromeleon Connect. Chromeleon CDS is also compatible with the S-Matrix® Fusion QbD® software package.

Automated column and eluent screening option
Screen up to 13 eluents by equipping your Vanquish Method Development HPLC and UHPLC system with a solvent selection valve for extensive, automated screening. The Thermo Scientific Viper Method Scouting Kit contains all the tubing and near-zero dead volume connections to screen four columns automatically without the need for any user interaction.

Universal and sensitive detection techniques
Detect all non- or semi-volatile analytes using a near-universal Thermo Scientific Charged Aerosol Detector. Additionally, gain more confidence in identification using the Thermo Scientific ISQ EC and EM single quadrupole mass detectors for peak identification and impurity profiling.

Automated, software-assisted method development
Automate, simplify and accelerate method development. The Vanquish Method Development HPLC and UHPLC systems are controlled by Chromeleon CDS and compatible with leading method development software packages, such as ChromSwordAuto Chromeleon Connect or Fusion QbD software.

Secure data storage
The Chromeleon Data Vault ensures secure data storage and accessibility for users within the CDS infrastructure. With Vanquish Method Development HPLC and UHPLC systems, all data generated is safely backed up in Chromeleon CDS Data Vault, enabling easy data exchange throughout the organization.

Optimized for small and large molecules
When built using Vanquish Flex and Vanquish Horizon UHPLC components, these systems are biocompatible, enabling robust performance, even with high-salt gradients, while minimizing unwanted interactions between the analyte and system components. ChromSwordAuto Chromeleon Connect includes dedicated algorithms for more efficient separations of large biomolecules.

Method validation
Automate design and execution of robustness testing using ChromSword AutoRobust Chromeleon Connect and accelerate your method validation using the workflows available in the Chromeleon 7 Extension Pack ICH templates.

For more information, download the Vanquish Method Development LC system product spotlight