Metrolab Blog

THERMO Scientific TSQ Altis Plus Triple Quadrupole Mass Spectrometer

Ultimate quantitative performance made possible

Highlights

Achieve the highest confidence in targeted compound detection and quantitation through leading sensitivity
Greater than 6 orders of linear dynamic range with high selectivity. Enhanced acquisition speeds empower large-scale studies for translational workflow development or method optimization with effective dwell time settings as low as 0.3 milliseconds — 5 millisecond polarity switching maximizes productivity in fewer experiments.
Where data confidence is required, the instrumental features on the TSQ AltisPlus triple quadrupole mass spectrometer drive high-performance targeted experiments for complex matrices.

High-throughput screening and quantitation
Innovations in the ion source, mass analyzer, active Q2 collision cell, and RF electronics offer high sensitivity, selectivity, and superior acquisition speeds/polarity switching times that are ideal with ultra-high performance liquid chromatography (UHPLC) separations. With scheduled SRM acquisition and 600 SRMs/second, 1000’s of compounds can be screened or quantified per method. Fast data acquisition reaches the number of required data points for outstanding confidence at extremely low concentrations, in the most challenging matrices.

Expanded experimental capabilities
Integrated workflow solutions centered on the TSQ Altis Plus mass spectrometer address regulated requirements targeting a growing list of diverse compounds. New UHPLC and ion chromatography (IC) systems maximize sample delivery and separation capabilities, maintaining the sensitivity to meet minimum residue limits without costly sample preparation or derivatization steps. Thermo Scientific Chromeleon Chromatographic Data System (CDS) software controls all experimental attributes in a regulated environment to further drive productivity.

Operational simplicity
Targeted research and routine applications demand fast and responsive instrument control software, with intuitive operations. Simplified calibration approach consolidates steps needed by the operator, combining an intelligent instrument check and calibration routine. Direct method transfer from the previous generation Thermo Scientific TSQ mass spectrometers can be performed for equal or better performance without optimization.
Experimental determination of dwell times assigned to each transition has been automated based on user-defined chromatographic peak width and the option of fixed cycle time or optimal number of data points per chromatographic peak. Prioritization settings allow further adjustments.

Database integration
Method development for targeted acquisition methods requires a prior knowledge of optimal product ions and energetics. Utilization of experimental libraries created from discovery experiments can by-pass the need for purified standards and lengthy optimization routines. The output from processed data in Thermo Scientific TraceFinder software can be directly imported into the instrument method editor, streamlining large-scale study creation.
Discovery experiments, however, may not contain all compounds targeted in a study. Integration with Thermo Scientific mzCloud databases enables selection of additional compounds from the most advanced mass spectral database to be added into existing experimental methods.

Explore next-level productivity with the TSQ plus mass spectrometer portfolio tour