Separation of oligonucleotides modified with disulfides

Due to the hydrophobic character of the disulfide units, a less hydrophobic stationary phase is necessary for the analysis of these modified oligonucleotides.

This application note shows how to achieve good peak shapes for the analysis of disulfide modified oligonucleotides using YMC-Triart Bio C4.

Download the application note with the full method details here.

Download your copy of YMC’s BioLC catalogue to receive more information on BioLC applications using YMC-Triart Bio C4 column or other BioLC columns.