Metrolab Blog

Sample Clean Up automation

Sample clean up is crucial for samples with complex matrices, such as biological fluids or food material. In fact, before proceeding with the injection into a LC or LC/MS system, the analytes of interest must be separated from the sample matrix.

This is a fundamental step to avoid that contaminants damage the analytical column or negatively affect the LC separation or the final detection. Sample clean up procedure can involve different steps:

  • sample derivatization with one or more buffers/reagents
  • sample heating at a set temperature for a fixed timing (to make some reactions – such as enzymatic digestion – occur
  • sample vortexing
  • sample clean up by SPE cartridges

Automation of sample clean up procedures assure higher reproducibility, increased productivity and even more sensitivity.

Discover HTA solutions for Sample Clean Up automation.