There is an urgent need for robust analytical methods for performing research on the measurement of opioids in complex biological matrices like blood and urine. For these dirty biological samples, sample preparation with solid phase extraction (SPE) results in cleaner samples which improves sample analysis by removing signal interferences. Microelution SPE can be used to concentrate samples up to 20 times for lower limits of detection. The Thermo Scientific™ SOLA™ SPE range uses innovative frit-less SPE technology which eliminates the issues with traditional loose-packed SPE formats. Combining the support material and active media components into a solid, uniform sorbent bed provides stable and controllable flow through characteristics and has an added advantage when dealing with viscous biological samples, as it prevents blocking and enables high throughput.
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