Metrolab Blog

Can a plastic well plate replace chromatography autosampler glass vials?

Glass-coated polypropylene (PP) plates have been on the market for decades now. They are a solution for customers who cannot use pure plastic plates due to either solvent compatibility issues or a loss of product due to adsorption on a pure plastic wall. Adsorption on cavity walls is the number one reason for poor reproducibility in bioanalysis. As the wall polarity in a glass-coated plate is inverted from non-polar to a polar surface, it has to be concluded that the risk of adsorption is significantly reduced.

The new 2nd generation plate+ products are made of high-quality PP, designed with state-of-the-art technology to deliver higher density coating (thickness of 200 nm), improved solvent stability, and better reproducibility, especially for highly on plastic walls adsorbing bio-molecules. The new 2nd generation plate+ products provide all usage benefits of a plastic well plate (robotic handling, multi pipette usage, etc.) with features of a glass surface at more attractive prices than a pure glass plate.

Download the related technical note here.