Metrolab Blog

YMC columns for chiral HPLC

Chirality has become vitally important in the production of pharmaceuticals, agrochemicals, food and related products due to the different pharmacological or taste/odour effects which the different optical isomers can present. The pharmacological effects can range from no activity through undesirable effects to having potentially life threatening adverse effects. This has led to the development of highly efficient CHIRAL stationary phases (CSP) for analytical and preparative scale separations.
If the CSP is available in two enantiomeric configurations the elution order of enantiomeric pairs can be reversed.
This is particularly useful when the two isomers are not present in equal quantities; a later eluting minor component can often be hidden by the tail of a major peak but on reversal of elution order can be totally resolved from the major component.

YMC offers several solutions for separating chiral compounds with different chiral selectors and different chiral separation mechanisms. The selectors are either coated/immobilised or bonded to the support material which has different pore sizes dependent on the selector. According to the selector chiral chromatography can be performed in NP, RP and/or SFC mode.

The following chiral phases/selectors are available:

  • Immobilised Polysaccharides (CHIRAL ART Amylose-SA and Cellulose-SB/SC/SJ)
  • Coated Polysaccharides (CHIRAL ART Amylose-C, Amylose-C Neo and Cellulose-C)
  • 1-Napthylethylamine (R- and S-)
  • Bromocyclodextrin (α-, β-, γ-)
  • Sumichiral OA selectors

For more information you can download our special brochure for YMC Chiral columns.