Metrolab Blog

THERMO Scientific | A fast HPAE-PAD method for determination of carbohydrates and glycols in pharmaceutical formulations

This study describes an HPAE-PAD assay for determination of six carbohydrates typically present in OTC pharmaceutical formulations in one chromatographic run. This assay was validated according to the analytical performance characteristics outlined in USP General Chapter <1225>, Validation of Compendial Procedures.
The results show that the method provides baseline separation for the six analytes. The method shows excellent precision for retention time as well as peak area, accurately measuring the typical concentrations of these analytes in commercial formulations. Moreover, the method is robust to experimental condition variations that may occur during routine use.

Read the detailed technical note.