Metrolab Blog

How to improve your analysis of challenging compounds


Are you plagued with poor peak shapes, low sensitivities, sample carryover, and/or low recoveries for challenging compounds?
 
Several substances are able to interact with the usual inert column hardware materials such as stainless steel or titanium. The adsorption on metallic surfaces typically leads to peak tailing, loss of recovery and sample carryover. Critical substances are especially metal-coordinating compounds, such as fumonisins, sphingophospholipids or organophosphates in general.
 
YMC offers a special hardware solution as an option for the YMC-Triart (U)HPLC column family. The so-called metal-free YMC-Triart columns are fully inert columns due to their PEEK-lined stainless steel column body and the use of PEEK frits.

By using YMC-Triart metal-free columns, superior peak shapes and sensitivities can be achieved making them the perfect choice for highly sensitive analyses using LC/MS.
 
For further information about the inert YMC-Triart metal-free columns, check out the YMC flyer which includes additional application examples.