A Fast Sample Preparation Procedure for Spray Dried Dispersion (SDD) Tablets Using Mechanical Assisted Extraction

Sample preparation is perhaps the most important step in tablet assay analysis as it requires complete extraction of the analyte and must yield a final solution concentration suitable for quantification.
In this work, the use of homogenization combined with wet milling for sample disintegration and extraction of Spray Dried Dispersion (SDD) tablets is discussed as a replacement to the lengthy manual method using sonication and mixing with stir bars in volumetric flasks.